Functional Regression

Functional data analysis (FDA) involves the analysis of data whose ideal units of observation are functions defined on some continuous domain, and the observed data consist of a sample of functions taken from some population, sampled on a discrete grid. Ramsay and Silverman's 1997 textbook sparked the development of this field, which has accelerated in the past 10 years to become one of the fastest growing areas of statistics, fueled by the growing number of applications yielding this type of data. One unique characteristic of FDA is the need to combine information both across and within functions, which Ramsay and Silverman called replication and regularization, respectively. This article will focus on functional regression, the area of FDA that has received the most attention in applications and methodological development. First will be an introduction to basis functions, key building blocks for regularization in functional regression methods, followed by an overview of functional regression methods, split into three types: [1] functional predictor regression (scalar-on-function), [2] functional response regression (function-on-scalar) and [3] function-on-function regression. For each, the role of replication and regularization will be discussed and the methodological development described in a roughly chronological manner, at times deviating from the historical timeline to group together similar methods. The primary focus is on modeling and methodology, highlighting the modeling structures that have been developed and the various regularization approaches employed. At the end is a brief discussion describing potential areas of future development in this field

Genomic and proteomic profiling for cancer diagnosis in dogs

Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in cancer diagnosis and prognosis. Many studies on canine tumours have focussed on RNA expression using techniques such as microarrays or next generation sequencing. However, proteomic studies combining two-dimensional polyacrylamide gel electrophoresis or two-dimensional differential gel electrophoresis with mass spectrometry have also provided a wealth of data on gene expression in tumour tissues. In addition, proteomics has been instrumental in the search for tumour biomarkers in blood and other body fluids

An Open Mapping Theorem

It is proved that any surjective morphism $f: \mathbb{Z}^\kappa \to K$ onto a locally compact group $K$ is open for every cardinal $\kappa$. This answers a question posed by Karl Heinrich Hofmann and the second author

Scheme Independence to all Loops

The immense freedom in the construction of Exact Renormalization Groups means that the many non-universal details of the formalism need never be exactly specified, instead satisfying only general constraints. In the context of a manifestly gauge invariant Exact Renormalization Group for SU(N) Yang-Mills, we outline a proof that, to all orders in perturbation theory, all explicit dependence of beta function coefficients on both the seed action and details of the covariantization cancels out. Further, we speculate that, within the infinite number of renormalization schemes implicit within our approach, the perturbative beta function depends only on the universal details of the setup, to all orders.Comment: 18 pages, 8 figures; Proceedings of Renormalization Group 2005, Helsinki, Finland, 30th August - 3 September 2005. v2: Published in jphysa; minor changes / refinements; refs. adde

String-Like Lagrangians from a Generalized Geometry

This note will use Hitchin's generalized geometry and a model of axionic gravity developed by Warren Siegel in the mid-nineties to show that the construction of Lagrangians based on the inner product arising from the pairing of a vector and its dual can lead naturally to the low-energy Lagrangian of the bosonic string.Comment: Conclusions basically unchanged, but presentation streamlined significantly. Published versio

Mobility Measurements Probe Conformational Changes in Membrane Proteins due to Tension

The function of membrane-embedded proteins such as ion channels depends crucially on their conformation. We demonstrate how conformational changes in asymmetric membrane proteins may be inferred from measurements of their diffusion. Such proteins cause local deformations in the membrane, which induce an extra hydrodynamic drag on the protein. Using membrane tension to control the magnitude of the deformations and hence the drag, measurements of diffusivity can be used to infer--- via an elastic model of the protein--- how conformation is changed by tension. Motivated by recent experimental results [Quemeneur et al., Proc. Natl. Acad. Sci. USA, 111 5083 (2014)] we focus on KvAP, a voltage-gated potassium channel. The conformation of KvAP is found to change considerably due to tension, with its `walls', where the protein meets the membrane, undergoing significant angular strains. The torsional stiffness is determined to be 26.8 kT at room temperature. This has implications for both the structure and function of such proteins in the environment of a tension-bearing membrane.Comment: Manuscript: 4 pages, 4 figures. Supplementary Material: 8 pages, 1 figur